{"id":343350,"date":"2026-01-20T17:40:08","date_gmt":"2026-01-20T16:40:08","guid":{"rendered":"https:\/\/miranza.es\/uncategorized\/we-advance-research-into-complex-endothelial-transplants\/"},"modified":"2026-01-20T17:49:30","modified_gmt":"2026-01-20T16:49:30","slug":"potenciamos-estudios-sobre-trasplantes-endoteliales-complejos","status":"publish","type":"post","link":"https:\/\/miranza.es\/en\/news\/potenciamos-estudios-sobre-trasplantes-endoteliales-complejos\/","title":{"rendered":"We advance research into complex endothelial transplants"},"content":{"rendered":"\n<p>Through research, Miranza, led by Dr. Jos\u00e9 Luis G\u00fcell, is developing a technique to facilitate the handling of the endothelial graft in complicated cases, as well as the temporary use of an inverted ICL for endothelial transplants in certain intraocular lens carriers.<\/p>\n\n\n\n<p>A new leap forward in ophthalmic innovation. We have advanced the treatment of <a href=\"https:\/\/miranza.es\/en\/treatments\/corneal-transplant\/\">corneal endothelial diseases<\/a> through the application of an endothelial transplant surgical technique (DMEK) in patients with particularly complex ocular anatomies.<\/p>\n\n\n\n<p>Corneal endothelial diseases are conditions that affect the cells of the innermost layer of the cornea\u2014<strong>the endothelium<\/strong>\u2014damaging their fluid-pumping function and causing corneal opacity and edema.<\/p>\n\n\n\n<p>The surgery in question, led by <strong>Dr. Jos\u00e9 Luis G\u00fcell, a specialist in corneal diseases at IMO Grupo Miranza<\/strong>, combines precision, innovation, and experience to deliver optimal visual outcomes, even in higher-risk cases.<\/p>\n\n\n\n<h2 class=\"wp-block-heading has-text-color has-link-color wp-elements-4d9f7c0572a43bf2489e71e00a09cf36\" style=\"color:#71cc98;font-size:25px\"><strong><strong><strong><strong><strong><strong><strong><strong>Surgical innovation: Small-Bubble Guided DMEK in complex eyes<\/strong><\/strong><\/strong><\/strong><\/strong><\/strong><\/strong><\/strong><\/h2>\n\n\n\n<p>In the field of corneal endothelial transplantation, Dr. Jos\u00e9 Luis G\u00fcell has developed a surgical technique known as <strong>Small-Bubble Guided DMEK<\/strong>, designed for patients with previously operated eyes or complex ocular anatomies, in whom this type of transplant is particularly difficult to perform.<\/p>\n\n\n\n<p>The endothelial graft\u2014an extremely thin tissue obtained from a donor cornea\u2014tends to fold onto itself, making its unfolding and positioning during surgery challenging. To overcome this difficulty, <strong>the technique is based on the very controlled injection of a small air bubble beneath the graft<\/strong>, which acts as temporary support during the procedure.<\/p>\n\n\n\n<p>This bubble counteracts the graft\u2019s tendency to roll up, facilitating a progressive, stable, and precise unfolding of the endothelial lenticule, even in anatomically demanding eyes. Once correctly positioned, intraocular gas is used to ensure firm adhesion to the posterior surface of the cornea.<\/p>\n\n\n\n<p><strong>The team\u2019s experience shows that this strategy improves intraoperative control of the graft<\/strong> and reduces deployment time by approximately half compared with other described techniques, resulting in safer and more reproducible procedures.<\/p>\n\n\n\n<p>According to Dr. Jos\u00e9 Luis G\u00fcell, \u201cone of the main challenges of DMEK in complex eyes is achieving proper graft unfolding without increasing surgical risk. The small bubble provides a key point of support to handle the tissue with greater precision.\u201d<\/p>\n\n\n\n<h2 class=\"wp-block-heading has-text-color has-link-color wp-elements-3895cb5448d2b9e8adcc0c6d0c0100e3\" style=\"color:#71cc98;font-size:25px\"><strong><strong><strong><strong><strong><strong><strong><strong>Clinical case: protection of the intraocular lens during endothelial transplantation<\/strong><\/strong><\/strong><\/strong><\/strong><\/strong><\/strong><\/strong><\/h2>\n\n\n\n<p>In a second line of innovation, Dr. Jos\u00e9 Luis G\u00fcell and his team have developed an original surgical strategy to protect <strong>hydrophilic intraocular lenses<\/strong> during endothelial transplantation, based on a recently published clinical case.<\/p>\n\n\n\n<p>During this type of surgery, intraocular gas is required to ensure proper graft adhesion to the cornea. However, in some patients with specific intraocular lenses, this gas can cause lens opacification and visual deterioration.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Through research, Miranza, led by Dr. Jos\u00e9 Luis G\u00fcell, is developing a technique to facilitate the handling of the endothelial graft in complicated cases, as well as the temporary use of an inverted ICL for endothelial transplants in certain intraocular lens carriers. A new leap forward in ophthalmic innovation. We have advanced the treatment of [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":343343,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"inline_featured_image":false,"footnotes":""},"categories":[4],"tags":[],"class_list":["post-343350","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-news"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.5 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>We advance research into complex endothelial transplants - Miranza<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/miranza.es\/en\/news\/potenciamos-estudios-sobre-trasplantes-endoteliales-complejos\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"We advance research into complex endothelial transplants - Miranza\" \/>\n<meta property=\"og:description\" content=\"Through research, Miranza, led by Dr. Jos\u00e9 Luis G\u00fcell, is developing a technique to facilitate the handling of the endothelial graft in complicated cases, as well as the temporary use of an inverted ICL for endothelial transplants in certain intraocular lens carriers. A new leap forward in ophthalmic innovation. We have advanced the treatment of [&hellip;]\" \/>\n<meta property=\"og:url\" content=\"https:\/\/miranza.es\/en\/news\/potenciamos-estudios-sobre-trasplantes-endoteliales-complejos\/\" \/>\n<meta property=\"og:site_name\" content=\"Miranza\" \/>\n<meta property=\"article:publisher\" content=\"https:\/\/www.facebook.com\/GrupoMiranza\/\" \/>\n<meta property=\"article:published_time\" content=\"2026-01-20T16:40:08+00:00\" \/>\n<meta property=\"article:modified_time\" content=\"2026-01-20T16:49:30+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/miranza.es\/wp-content\/uploads\/2026\/01\/Dr.-Guell.jpg\" \/>\n\t<meta property=\"og:image:width\" content=\"1577\" \/>\n\t<meta property=\"og:image:height\" content=\"1051\" \/>\n\t<meta property=\"og:image:type\" content=\"image\/jpeg\" \/>\n<meta name=\"author\" content=\"Equipo Miranza\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:creator\" content=\"@GrupoMiranza\" \/>\n<meta name=\"twitter:site\" content=\"@GrupoMiranza\" \/>\n<meta name=\"twitter:label1\" content=\"Written by\" \/>\n\t<meta name=\"twitter:data1\" content=\"Equipo Miranza\" \/>\n\t<meta name=\"twitter:label2\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data2\" content=\"3 minutes\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\\\/\\\/schema.org\",\"@graph\":[{\"@type\":\"Article\",\"@id\":\"https:\\\/\\\/miranza.es\\\/en\\\/news\\\/potenciamos-estudios-sobre-trasplantes-endoteliales-complejos\\\/#article\",\"isPartOf\":{\"@id\":\"https:\\\/\\\/miranza.es\\\/en\\\/news\\\/potenciamos-estudios-sobre-trasplantes-endoteliales-complejos\\\/\"},\"author\":{\"name\":\"Equipo Miranza\",\"@id\":\"https:\\\/\\\/miranza.es\\\/en\\\/#\\\/schema\\\/person\\\/e01c042f39bcd4da7bc9b77d6e23bf76\"},\"headline\":\"We advance research into complex endothelial transplants\",\"datePublished\":\"2026-01-20T16:40:08+00:00\",\"dateModified\":\"2026-01-20T16:49:30+00:00\",\"mainEntityOfPage\":{\"@id\":\"https:\\\/\\\/miranza.es\\\/en\\\/news\\\/potenciamos-estudios-sobre-trasplantes-endoteliales-complejos\\\/\"},\"wordCount\":449,\"publisher\":{\"@id\":\"https:\\\/\\\/miranza.es\\\/en\\\/#organization\"},\"image\":{\"@id\":\"https:\\\/\\\/miranza.es\\\/en\\\/news\\\/potenciamos-estudios-sobre-trasplantes-endoteliales-complejos\\\/#primaryimage\"},\"thumbnailUrl\":\"https:\\\/\\\/miranza.es\\\/wp-content\\\/uploads\\\/2026\\\/01\\\/Dr.-Guell.jpg\",\"articleSection\":[\"News\"],\"inLanguage\":\"en-US\"},{\"@type\":\"WebPage\",\"@id\":\"https:\\\/\\\/miranza.es\\\/en\\\/news\\\/potenciamos-estudios-sobre-trasplantes-endoteliales-complejos\\\/\",\"url\":\"https:\\\/\\\/miranza.es\\\/en\\\/news\\\/potenciamos-estudios-sobre-trasplantes-endoteliales-complejos\\\/\",\"name\":\"We advance research into complex endothelial transplants - Miranza\",\"isPartOf\":{\"@id\":\"https:\\\/\\\/miranza.es\\\/en\\\/#website\"},\"primaryImageOfPage\":{\"@id\":\"https:\\\/\\\/miranza.es\\\/en\\\/news\\\/potenciamos-estudios-sobre-trasplantes-endoteliales-complejos\\\/#primaryimage\"},\"image\":{\"@id\":\"https:\\\/\\\/miranza.es\\\/en\\\/news\\\/potenciamos-estudios-sobre-trasplantes-endoteliales-complejos\\\/#primaryimage\"},\"thumbnailUrl\":\"https:\\\/\\\/miranza.es\\\/wp-content\\\/uploads\\\/2026\\\/01\\\/Dr.-Guell.jpg\",\"datePublished\":\"2026-01-20T16:40:08+00:00\",\"dateModified\":\"2026-01-20T16:49:30+00:00\",\"breadcrumb\":{\"@id\":\"https:\\\/\\\/miranza.es\\\/en\\\/news\\\/potenciamos-estudios-sobre-trasplantes-endoteliales-complejos\\\/#breadcrumb\"},\"inLanguage\":\"en-US\",\"potentialAction\":[{\"@type\":\"ReadAction\",\"target\":[\"https:\\\/\\\/miranza.es\\\/en\\\/news\\\/potenciamos-estudios-sobre-trasplantes-endoteliales-complejos\\\/\"]}]},{\"@type\":\"ImageObject\",\"inLanguage\":\"en-US\",\"@id\":\"https:\\\/\\\/miranza.es\\\/en\\\/news\\\/potenciamos-estudios-sobre-trasplantes-endoteliales-complejos\\\/#primaryimage\",\"url\":\"https:\\\/\\\/miranza.es\\\/wp-content\\\/uploads\\\/2026\\\/01\\\/Dr.-Guell.jpg\",\"contentUrl\":\"https:\\\/\\\/miranza.es\\\/wp-content\\\/uploads\\\/2026\\\/01\\\/Dr.-Guell.jpg\",\"width\":1577,\"height\":1051},{\"@type\":\"BreadcrumbList\",\"@id\":\"https:\\\/\\\/miranza.es\\\/en\\\/news\\\/potenciamos-estudios-sobre-trasplantes-endoteliales-complejos\\\/#breadcrumb\",\"itemListElement\":[{\"@type\":\"ListItem\",\"position\":1,\"name\":\"Home\",\"item\":\"https:\\\/\\\/miranza.es\\\/en\\\/\"},{\"@type\":\"ListItem\",\"position\":2,\"name\":\"News\",\"item\":\"https:\\\/\\\/miranza.es\\\/en\\\/category\\\/news\\\/\"},{\"@type\":\"ListItem\",\"position\":3,\"name\":\"We advance research into complex endothelial transplants\"}]},{\"@type\":\"WebSite\",\"@id\":\"https:\\\/\\\/miranza.es\\\/en\\\/#website\",\"url\":\"https:\\\/\\\/miranza.es\\\/en\\\/\",\"name\":\"Miranza\",\"description\":\"Somos tus centros de excelencia, especialistas en bienestar ocular. 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